Low-Resistance Mechanism of Nanoflake Crystalline Aromatic Dicarboxylates with Selective Defects for Safe and Fast Charging Negative Electrodes

Low-Resistance Mechanism of Nanoflake Crystalline Aromatic Dicarboxylates with Selective Defects for Safe and Fast Charging Negative Electrodes

Low resistance of Li-intercalated unfavourable electrodes is essential for the secure and quick charging required for large-scale batteries. Right here, we demonstrated that nanosized two-dimensional crystalline fragrant dicarboxylate unfavourable electrode supplies synthesized through spray drying exhibit low inside resistances at roughly 0.7 V vs Li/Li+, whereas retaining flat potential profiles. The spray-dried pattern with a hole construction is crushed into nanoflakes throughout ink preparation for electrode coating and kinds a uniform and extremely dispersed electrode construction.

The charge-discharge analysis signifies that the nanoflake pattern confirmed smaller charge-discharge polarization than the majority pattern with secure biking traits, leading to vital high-rate property enhancement. Cost-transfer resistance of the nanoflake pattern reveals the bottom worth (ca. 2.2 Ω cm2) amongst these reported for current intercalation electrodes (5.2 to 235 Ω cm2). Compared of the unfavourable electrodes, the estimated most present density with out Li deposition (ca. 316 mA cm-2) is greater than 1 order of magnitude larger than that for at present used graphite (ca. 11 mA cm-2) and can also be larger than these for high-rate oxides (137-298 mA cm-2).

The resistance-crystal correlation utilizing a number of regression evaluation predictions and its verification reveal that this low resistance is owing to an improved Li acceptability related to selective structural defects induced by the lack of included crystallized water throughout drying. The crystal aircraft uncovered by the selective structural defects is perpendicular to digital and ionic conduction instructions contained in the stable, leading to improved kinetics. Subsequently, the proposed unfavourable electrode permits secure and quick charging, with straightforward scale-up and sustainable sources.

Purposeful Genomics Approaches to Elucidate Vulnerabilities of Intrinsic and Acquired Chemotherapy Resistance

Drug resistance is a generally unavoidable consequence of most cancers remedy that ends in remedy failure and illness relapse. Intrinsic (pre-existing) or acquired resistance mechanisms could be drug-specific or be relevant to a number of medicine, leading to multidrug resistance. The presence of drug resistance is, nonetheless, tightly coupled to modifications in mobile homeostasis, which might result in resistance-coupled vulnerabilities. Unbiased gene perturbations by way of RNAi and CRISPR applied sciences are invaluable instruments to determine genotype-to-phenotype relationships on the genome scale.

Furthermore, their software to most cancers cell strains can uncover new vulnerabilities which are related to resistance mechanisms. Right here, we focus on focused and unbiased RNAi and CRISPR efforts within the discovery of drug resistance mechanisms by specializing in first-in-line chemotherapy and their enforced vulnerabilities, and we current a view ahead on which measures ought to be taken to speed up their medical translation.

Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic most cancers

Stromal fibrosis prompts pro-survival and pro-epithelial-to-mesenchymal transition (EMT) pathways in pancreatic ductal adenocarcinoma (PDAC). In affected person tumors handled with neoadjuvant stereotactic physique radiation remedy (SBRT), we discovered upregulation of fibrosis, extracellular matrix (ECM), and EMT gene signatures, which might drive therapeutic resistance and tumor invasion. Molecular, practical, and translational evaluation recognized two cell floor proteins, A disintegrin and metalloprotease 10 (ADAM10) and ephrinB2, as drivers of fibrosis and tumor development after RT. RT resulted in elevated ADAM10 expression in tumor cells, resulting in cleavage of ephrinB2, which was additionally detected in plasma.
Pharmacologic or genetic focusing on of ADAM10 decreased RT-induced fibrosis and tissue rigidity, tumor cell migration, and invasion, sensitizing orthotopic tumors to radiation killing and prolonging mouse survival. Inhibition of ADAM10 and genetic ablation of ephrinB2 in fibroblasts decreased the metastatic potential of tumor cells after RT. Stimulation of tumor cells with EphrinB2 FC-protein reversed the discount in tumor cell invasion with ADAM10 ablation. These findings signify a mannequin of PDAC adaptation that explains resistance and metastasis after radiation remedy and identifies a targetable pathway to reinforce RT efficacy.

Exogenous and endogenous sources of serine contribute to colon most cancers metabolism, development, and resistance to 5-fluorouracil

Serine is a non-essential amino acid generated by the sequential actions of phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT1), and phosphoserine phosphatase (PSPH). Elevated serine biosynthesis happens in a number of cancers and helps tumor development. Moreover, most cancers cells can harness exogenous serine to reinforce their metabolism and proliferation. Right here we examined the relative contributions of exogenous and endogenous sources of serine on the biology of colorectal most cancers (CRC). In murine tumors, Apc standing was recognized as a determinant of the expression of genes controlling serine synthesis.
Low-Resistance Mechanism of Nanoflake Crystalline Aromatic Dicarboxylates with Selective Defects for Safe and Fast Charging Negative Electrodes
In affected person samples, PSAT1 was overexpressed in each colorectal adenomas and adenocarcinomas. Combining genetic deletion of PSAT1 with exogenous serine deprivation maximally suppressed the proliferation of CRC cells and induced profound metabolic defects together with diminished nucleotide manufacturing. Inhibition of serine synthesis enhanced the transcriptional modifications following exogenous serine elimination in addition to alterations related to DNA injury.

Human Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) ELISA Kit

RD-BCAR1-Hu-48Tests 48 Tests
EUR 521

Human Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) ELISA Kit

RD-BCAR1-Hu-96Tests 96 Tests
EUR 723

Bcar1/ Rat Bcar1 ELISA Kit

ELI-24478r 96 Tests
EUR 886

BCAR1 antibody

70R-15968 50 ul
EUR 435
Description: Rabbit polyclonal BCAR1 antibody

BCAR1 Antibody

37147-100ul 100ul
EUR 252

BCAR1 antibody

10R-3418 100 ul
EUR 691
Description: Mouse monoclonal BCAR1 antibody

BCAR1 antibody

10R-3420 100 ul
EUR 691
Description: Mouse monoclonal BCAR1 antibody

BCAR1 antibody

10R-3421 100 ul
EUR 726
Description: Mouse monoclonal BCAR1 antibody

BCAR1 Antibody

1-CSB-PA002593GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
  • Form: Liquid
  • Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF

BCAR1 Antibody

1-CSB-PA002593LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

BCAR1 Antibody

1-CSB-PA003613
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

BCAR1 Antibody

1-CSB-PA003614
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

BCAR1 Antibody

1-CSB-PA134376
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100

BCAR1 Antibody

1-CSB-PA941444
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Antigen affinity purification
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

BCAR1 siRNA

20-abx900603
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

BCAR1 siRNA

20-abx908938
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

BCAR1 siRNA

20-abx908939
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

anti-BCAR1

YF-PA16392 50 ul
EUR 363
Description: Mouse polyclonal to BCAR1

anti-BCAR1

YF-PA16393 50 ug
EUR 363
Description: Mouse polyclonal to BCAR1

anti-BCAR1

YF-PA16394 100 ug
EUR 403
Description: Rabbit polyclonal to BCAR1

BCAR1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV672493 1.0 ug DNA
EUR 1355

BCAR1 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV672497 1.0 ug DNA
EUR 1355

BCAR1 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV672498 1.0 ug DNA
EUR 1355

Bcar1 ORF Vector (Rat) (pORF)

ORF063985 1.0 ug DNA
EUR 506

BCAR1 ORF Vector (Human) (pORF)

ORF016109 1.0 ug DNA
EUR 405

Bcar1 ORF Vector (Mouse) (pORF)

ORF039734 1.0 ug DNA
EUR 506

Bcar1 ORF Vector (Mouse) (pORF)

ORF039735 1.0 ug DNA
EUR 506

BCAR1 Rabbit pAb

A0855-100ul 100 ul
EUR 308

BCAR1 Rabbit pAb

A0855-200ul 200 ul
EUR 459

BCAR1 Rabbit pAb

A0855-20ul 20 ul Ask for price

BCAR1 Rabbit pAb

A0855-50ul 50 ul
EUR 223

BCAR1 Conjugated Antibody

C37147 100ul
EUR 397

BCAR1 (pY410) Antibody

abx333314-100ul 100 ul
EUR 467
  • Shipped within 5-10 working days.

BCAR1 Rabbit pAb

A18270-100ul 100 ul
EUR 308

BCAR1 Rabbit pAb

A18270-200ul 200 ul
EUR 459

BCAR1 Rabbit pAb

A18270-20ul 20 ul
EUR 183

BCAR1 Rabbit pAb

A18270-50ul 50 ul
EUR 223

Anti-BCAR1 antibody

STJ11100226 100 µl
EUR 277
Description: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer.

Anti-BCAR1 antibody

STJ22766 100 µl
EUR 277

Anti-BCAR1 antibody

STJ73016 100 µg
EUR 359

BCAR1 Antibody, HRP conjugated

1-CSB-PA002593LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

BCAR1 Antibody, FITC conjugated

1-CSB-PA002593LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

BCAR1 Antibody, Biotin conjugated

1-CSB-PA002593LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against BCAR1. Recognizes BCAR1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Phospho-BCAR1 (Y410) Antibody

1-CSB-PA080024
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-BCAR1 (Y410). Recognizes Phospho-BCAR1 (Y410) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-BCAR1 (Y165) Antibody

1-CSB-PA080025
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-BCAR1 (Y165). Recognizes Phospho-BCAR1 (Y165) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-BCAR1 (Y249) Antibody

1-CSB-PA080026
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-BCAR1 (Y249). Recognizes Phospho-BCAR1 (Y249) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

BCAR1 (Ab-410) Antibody

CSB-PA094765-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against BCAR1 (Ab-410). Recognizes BCAR1 (Ab-410) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

BCAR1 (Ab-410) Antibody

CSB-PA094765-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against BCAR1 (Ab-410). Recognizes BCAR1 (Ab-410) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

Phospho-BCAR1 (Tyr410) Antibody

CSB-PA975216-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodie
  • Show more
Description: A polyclonal antibody against Phospho-BCAR1 (Tyr410). Recognizes Phospho-BCAR1 (Tyr410) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-BCAR1 (Tyr410) Antibody

CSB-PA975216-100ul 100ul
EUR 362
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodie
  • Show more
Description: A polyclonal antibody against Phospho-BCAR1 (Tyr410). Recognizes Phospho-BCAR1 (Tyr410) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

BCAR1 protein (His tag)

80R-3671 50 ug
EUR 435
Description: Purified recombinant BCAR1 protein (His tag)

Human BCAR1 ELISA KIT

ELI-25200h 96 Tests
EUR 824

BCAR1 ELISA KIT|Human

EF006635 96 Tests
EUR 689

Rat BCAR1 shRNA Plasmid

20-abx985003
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

BCAR1 Cell ELISA Kit

abx595057-96tests 96 tests
EUR 637
  • Shipped within 1-2 weeks.

Human BCAR1 shRNA Plasmid

20-abx956363
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Mouse BCAR1 shRNA Plasmid

20-abx969811
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Mouse Bcar1 ELISA KIT

ELI-33323m 96 Tests
EUR 865

BCAR1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV672494 1.0 ug DNA
EUR 1355

BCAR1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV672495 1.0 ug DNA
EUR 1413

BCAR1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV672496 1.0 ug DNA
EUR 1413

BCAR1 Protein Vector (Mouse) (pPB-C-His)

PV158934 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPB-N-His)

PV158935 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPM-C-HA)

PV158936 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPM-C-His)

PV158937 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPB-C-His)

PV158938 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPB-N-His)

PV158939 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPM-C-HA)

PV158940 500 ng
EUR 1065

BCAR1 Protein Vector (Mouse) (pPM-C-His)

PV158941 500 ng
EUR 1065

BCAR1 Protein Vector (Rat) (pPB-C-His)

PV255938 500 ng
EUR 1166

BCAR1 Protein Vector (Rat) (pPB-N-His)

PV255939 500 ng
EUR 1166

BCAR1 Protein Vector (Rat) (pPM-C-HA)

PV255940 500 ng
EUR 1166

BCAR1 Protein Vector (Rat) (pPM-C-His)

PV255941 500 ng
EUR 1166

BCAR1 Protein Vector (Human) (pPB-His-MBP)

PV326406 500 ng
EUR 811

BCAR1 Protein Vector (Human) (pPB-His-GST)

PV326407 500 ng
EUR 811

BCAR1 Protein Vector (Human) (pPB-C-His)

PV064433 500 ng
EUR 811

BCAR1 Protein Vector (Human) (pPB-N-His)

PV064434 500 ng
EUR 811

BCAR1 Protein Vector (Human) (pPM-C-HA)

PV064435 500 ng
EUR 811

BCAR1 Protein Vector (Human) (pPM-C-His)

PV064436 500 ng
EUR 811

Polyclonal MOUSE Bcar1 Antibody (Center)

APR04569G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MOUSE Bcar1 (Center). This antibody is tested and proven to work in the following applications:

Phospho-BCAR1-Y410 Rabbit pAb

AP0789-100ul 100 ul
EUR 384

Phospho-BCAR1-Y410 Rabbit pAb

AP0789-200ul 200 ul
EUR 554

Phospho-BCAR1-Y410 Rabbit pAb

AP0789-20ul 20 ul
EUR 183

Phospho-BCAR1-Y410 Rabbit pAb

AP0789-50ul 50 ul
EUR 265

Phospho-BCAR1-Y165 Rabbit pAb

AP0813-100ul 100 ul
EUR 384

Phospho-BCAR1-Y165 Rabbit pAb

AP0813-200ul 200 ul
EUR 554

Phospho-BCAR1-Y165 Rabbit pAb

AP0813-20ul 20 ul
EUR 183

Phospho-BCAR1-Y165 Rabbit pAb

AP0813-50ul 50 ul
EUR 265

Phospho-BCAR1-Y410 Rabbit pAb

AP1058-100ul 100 ul
EUR 384

Phospho-BCAR1-Y410 Rabbit pAb

AP1058-200ul 200 ul
EUR 554

Phospho-BCAR1-Y410 Rabbit pAb

AP1058-20ul 20 ul
EUR 183

Phospho-BCAR1-Y410 Rabbit pAb

AP1058-50ul 50 ul
EUR 265

Polyclonal BCAR1 Antibody (internal region)

APG00909G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human BCAR1 (internal region). This antibody is tested and proven to work in the following applications:

BCAR1 (pY410) Cell ELISA Kit

abx595988-296tests 2 × 96 tests
EUR 707
  • Shipped within 1-2 weeks.

Anti-Phospho-BCAR1-Y410 antibody

STJ11101096 100 µl
EUR 393
Description: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer.

Anti-Phospho-BCAR1-(Y410) antibody

STJ117887 100 µl
EUR 393

Anti-Phospho-BCAR1-(Y165) antibody

STJ117911 100 µl
EUR 393

BCAR1 ELISA Kit (Human) (OKCD01928)

OKCD01928 96 Wells
EUR 831
Description: Description of target: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 27 pg/mL

BCAR1 Colorimetric Cell-Based ELISA Kit

EKC1054 100ul
EUR 572

Bcar1 sgRNA CRISPR Lentivector set (Rat)

K6802201 3 x 1.0 ug
EUR 339

BCAR1 sgRNA CRISPR Lentivector set (Human)

K0173301 3 x 1.0 ug
EUR 339

Bcar1 sgRNA CRISPR Lentivector set (Mouse)

K3814401 3 x 1.0 ug
EUR 339

BCAR1 Protein Vector (Human) (pPM-N-D-C-HA)

PV326408 500 ng Ask for price

BCAR1 Protein Vector (Human) (pPM-N-D-C-His)

PV326409 500 ng Ask for price

Bcar1 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6802202 1.0 ug DNA
EUR 154

Bcar1 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6802203 1.0 ug DNA
EUR 154

Bcar1 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6802204 1.0 ug DNA
EUR 154

BCAR1 sgRNA CRISPR Lentivector (Human) (Target 1)

K0173302 1.0 ug DNA
EUR 154

BCAR1 sgRNA CRISPR Lentivector (Human) (Target 2)

K0173303 1.0 ug DNA
EUR 154

BCAR1 sgRNA CRISPR Lentivector (Human) (Target 3)

K0173304 1.0 ug DNA
EUR 154

Bcar1 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3814402 1.0 ug DNA
EUR 154

Bcar1 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3814403 1.0 ug DNA
EUR 154

Bcar1 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3814404 1.0 ug DNA
EUR 154

Recombinant Human BCAR1 Protein, His, E.coli-10ug

QP11133-10ug 10ug
EUR 201

Recombinant Human BCAR1 Protein, His, E.coli-1mg

QP11133-1mg 1mg
EUR 5251

Recombinant Human BCAR1 Protein, His, E.coli-2ug

QP11133-2ug 2ug
EUR 155

Bcar1 3'UTR GFP Stable Cell Line

TU152663 1.0 ml Ask for price

Bcar1 3'UTR Luciferase Stable Cell Line

TU102663 1.0 ml Ask for price

Bcar1 3'UTR Luciferase Stable Cell Line

TU201255 1.0 ml Ask for price

Bcar1 3'UTR GFP Stable Cell Line

TU251255 1.0 ml Ask for price

BCAR1 3'UTR GFP Stable Cell Line

TU051676 1.0 ml
EUR 1394

BCAR1 3'UTR Luciferase Stable Cell Line

TU001676 1.0 ml
EUR 1394

BCAR1 Colorimetric Cell-Based ELISA Kit (OKAG00547)

OKAG00547 96 Wells
EUR 596
Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibody

20-abx213819
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibody

20-abx214090
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) Antibody

20-abx111258
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.
Each lack of PSAT1 and elimination of serine from the weight loss plan had been essential to suppress CRC xenograft development and improve the anti-tumor exercise of 5-fluorouracil (5-FU). Limiting endogenous and exogenous serine in vitro augmented 5-FU induced cell dying, DNA injury, and metabolic perturbations, probably accounting for the noticed anti-tumor impact. Collectively, our outcomes counsel that each endogenous and exogenous sources of serine contribute to CRC development and resistance to 5-FU.

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